Evolution, geographic spreading, and demographic distribution of Enterovirus D68엔테로바이러스 D68의 진화, 지리적 확산 및 인구통계학적 분포Article Published on 2022-05-312022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Adults age age distribution antigenic evolution Asia Asian Better bimodal caused children circulating Cluster collected Critical diagnostic distribution East enterovirus Enterovirus D68 Epitopes Europe European country Evolution explained full-length genome Immunity Neurological disease neutralizing epitope Older outbreak pandemic Pathogens Patient pattern Phylogenetic Reinfection SARS-CoV-2 sequence significantly strain Strains subclades subgroup surface proteins USA variant viral pathogens virus whole genome [DOI] 10.1371/journal.ppat.1010515 PMC 바로가기 [Article Type] Article
Evolutionary Dynamics of Mexican Lineage H5N2 Avian Influenza VirusesArticle Published on 2022-05-032023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] antigenic evolution genetic and phylogenetic analyses H5N2 avian influenza virus selection pressure. [DOI] 10.3390/v14050958 PMC 바로가기
Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity항원 진화는 예측할 수 없는 심각성을 가진 새로운 SARS-CoV-2 변이체로 이어질 것입니다Article Published on 2022-05-012022-09-11 Journal: Nature reviews. Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antigenic evolution coincidence Evolution Immunity milder infection new SARS-CoV-2 omicron Omicron variant pandemic population immunity raised severity variant weakening [DOI] 10.1038/s41579-022-00722-z PMC 바로가기 [Article Type] Article
Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994-2019 in ChinaArticle Published on 2022-03-302023-05-31 Journal: Viruses [Category] 신종인플루엔자, 조류인플루엔자, [키워드] antigenic evolution Avian influenza viruses H9N2 hemagglutinin. [DOI] 10.3390/v14040726 PMC 바로가기
Genetic and Antigenic Characterization of an Influenza A(H3N2) Outbreak in Cambodia and the Greater Mekong Subregion during the COVID-19 Pandemic, 20202020년 COVID-19 팬데믹 기간 동안 캄보디아 및 광역 메콩 소지역에서 인플루엔자 A(H3N2) 발병의 유전 및 항원 특성 분석Genetic Diversity and Evolution Published on 2021-09-292022-09-10 Journal: Journal of Virology [Category] MERS, SARS, 치료기술, [키워드] 2019 coronavirus disease A(H3N2) Analysis antigenic evolution Asia Cambodia characterization characterized circulation component coronavirus coronavirus disease country COVID-19 decrease Epidemic Epidemics event for inclusion Genetic Hemisphere in some Inclusion Infection Influenza influenza A influenza vaccine Intervention Laos maintenance measure Mekong Migration occurred outbreak pandemic PDR Phylogenetic analysis prototype virus reduction in remained respiratory Respiratory disease respiratory diseases resulting SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly Surveillance the WHO these viruses Vaccine Vietnam virus virus viruses was performed WHO [DOI] 10.1128/JVI.01267-21 PMC 바로가기 [Article Type] Genetic Diversity and Evolution
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infectionmRNA-1273 백신 접종에 의해 유도된 항체는 SARS-CoV-2 감염에서보다 수용체 결합 도메인에 더 광범위하게 결합합니다Research Article Published on 2021-06-302022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity affected antibodies antibody antibody epitope antibody epitopes antibody immunity Antibody Response Antibody responses antigenic evolution binding breadth characterized convalescent sera coronavirus deep demonstrated dose elicited epitope Epitopes erosion greater human antibody response Immunity immunization Infection less Moderna mRNA-1273 vaccine mRNA mRNA-1273 mRNA-1273 COVID-19 vaccine Mutation natural infection neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody polyclonal antibodies polyclonal antibody raised RBD RBD mutation RBD-binding antibody Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein sera severe acute respiratory syndrome Coronavirus specificity Spike protein susceptibility the antibody response the RBD the receptor-binding domain the SARS-CoV-2 vaccination Vaccine variant variants Viral viral evolution viral mutation Viral mutations [DOI] 10.1126/scitranslmed.abi9915 PMC 바로가기 [Article Type] Research Article
Antigenic Evolution on a Global Scale Reveals the Potential Natural Selection of Severe Acute Respiratory Syndrome-Coronavirus 2 by Pre-existing Cross-Reactive T-Cell ImmunityMicrobiology Published on 2021-05-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Amino acid antigenic evolution B-cell cellular immunity changed changes in circulating community transmission comprehensive analysis coronavirus cross-reactive docking ENhance Evolution Guidance help homology host cell host immune system Immunity Mutation mutations natural natural selection ORF1ab peptide Potential pre-existing cross-reactive T-cell immunity Protein provided Research respiratory SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 strain scale seasonal human coronavirus Selection selective severe acute respiratory syndrome-coronavirus 2 spike susceptible T-cell epitope Vaccine design virus [DOI] 10.3389/fmicb.2021.599562 PMC 바로가기 [Article Type] Microbiology
Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimesSARS-CoV-2 백신 투여 요법의 역학 및 진화적 고려 사항Research Article Published on 2021-04-232022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단, [키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Affect antigenic evolution approach approved assumption available dose available doses build building can be used Characteristics clinical evaluation Combination condition consequence continuous spectrum coronavirus country COVID-19 infection COVID-19 infections Critical decrease dependent on determine disease severity distribution dose dosing regimen effective vaccine effort elicited epidemiological equity Evolution example first dose highlight immune Immune escape immune response immune responses Immunity immunized Impact imperative improves in some increase increase in individual individual immunity individuals Infection infections International Intervention long term medium middle mitigate mutations natural immunity Numerous outcome outcomes pandemic parameters phylodynamic population immunity Primary infection problems proportion public policies question rationale receiving reduce reduced replicate respiratory resulting robustness Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 viral Science second dose secondary infections serological data severe acute respiratory syndrome Coronavirus short term single dose single vaccine Spread strength Stress subsequent susceptibility susceptible switching the timing the vaccine trajectory vaccinal vaccination vaccination rate vaccination rates Vaccine vaccine dose Vaccines variants Variation variations Viral viral adaptation viral antigenic evolution Viral load viral loads virus [DOI] 10.1126/science.abg8663 PMC 바로가기 [Article Type] Research Article
A human coronavirus evolves antigenically to escape antibody immunity인간 코로나 바이러스는 항체 면역을 피하기 위해 항원 적으로 진화합니다.Research Article Published on 2021-04-082022-08-13 Journal: PLoS Pathogens [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] 229E 229E strain 229E strains 229E viral strain 229E viruses accumulate anti-SARS-CoV-2 titer anti-SARS-CoV-2 titers antibody antibody immunity antigenic evolution common-cold comparable coronavirus coronavirus coronavirus 229E coronavirus vaccine Coronavirus vaccines Coronaviruses degrade elicited Evolution Hope Human coronavirus human coronavirus 229E human sera Hypothesis identify Immunity in some individuals Infection less Mutation neutralization neutralize Neutralizing titer neutralizing titers NTD occur Older other coronaviruses pace PROTECT question re-infect Re-infection Re-infections Receptor-binding domain Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines seasonal coronavirus sera Spike protein strain Strains subsequent the RBD the receptor-binding domain titers vaccination variants of SARS-CoV-2 Viral viral evolution viral mutation Viral mutations viral spike viral strains virus virus viruses was collected [DOI] 10.1371/journal.ppat.1009453 PMC 바로가기 [Article Type] Research Article
Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016Report Published on 2021-04-052022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, [키워드] Abstract addition Affect amino acid change antibody Antibody binding antibody cocktail antibody escape antigenic evolution B.1.351 B.1.429 bamlanivimab binding circulating Combination Complete coronavirus disease COVID-19 deep mutational scanning E484K Effect Efficacy effort epitope Evolution highlight identify individual Interpretation L452R Lineage LY-CoV555 Map monoclonal antibody Mutation P.1 Prophylaxis RBD SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 mutation SARS-CoV-2 RBD spike receptor-binding domain the SARS-CoV-2 therapeutic Therapeutic antibody variants of concern Variation [DOI] 10.1016/j.xcrm.2021.100255 PMC 바로가기 [Article Type] Report